GENERAL TERMS AND CONDITIONS FOR THE USE OF THE PLATFORM "ZYMSCAN"

PRELIMINARY PROVISIONS:

ZYMSCAN is a platform designed to suggest enzymes capable of carrying out a specific reaction proposed by the USER. This platform has been developed by ZYMVOL BIOMODELING, S.L. (hereinafter referred to as "ZYMVOL" or "OWNER").

This document (together with all documents mentioned herein) establishes the clauses governing the GENERAL TERMS AND CONDITIONS OF USE OF THE PLATFORM "ZYMSCAN" (hereinafter, "T&C") provided by the OWNER through the Website <zymbrain.ai> (hereinafter referred to as the "Website").

These T&C are designed to provide transparency in the use, registration, conditions, as well as to inform the USER about the collection and storage of information through the use of the platform.

These T&C complement the other legal notices on our Website, and therefore, before accessing, registering, browsing, and using ZYMSCAN, the OWNER expressly requests the USER to carefully read these General Terms and Conditions of Use, the Legal Notice, the Privacy Policy, and the Cookie Policy. In case of any questions arise, please contact us via email at zymscan@zymvol.com.

HEADINGS:

• OWNER.
• USER.
• ACCEPTANCE.
• DEFINITIONS.
• DESCRIPTION OF SERVICE AND OPERATION OF THE PLATFORM.
• AUTHORIZATION OF USE.
• USER-SUBMITTED CONTENT.
• OWNER'S OBLIGATIONS.
• USER'S OBLIGATIONS AND PROHIBITIONS.
• WARRANTIES.
• LIABILITIES.
• SERVICE SUSPENSION.
• TERMINATION.
• INTELLECTUAL AND INDUSTRIAL PROPERTY PROTECTION.
• SEARCH RESULTS PROTECTION.
• HARDWARE AND SOFTWARE REQUIREMENTS.
• TECHNICAL SUPPORT.
• PLATFORM MODIFICATION AND UPDATES.
• NULLITY AND INEFFECTIVENESS OF CLAUSES.
• GENERAL PROVISIONS.
• PRIVACY POLICY AND COOKIES.
• APPLICABLE LAW AND JURISDICTION.
• COMMENTS, SUGGESTIONS, COMPLAINTS, AND CLAIMS.

OWNER:

The OWNER of the platform ZYMSCAN is ZYMVOL BIOMODELING, S.L., Spanish company, having its principal place of business at Carrer Pau Claris 94, 3ºB, 08010 Barcelona, Spain and tax identification number B25825563.

USER:

Accessing, browsing the Website <zymbrain.ai>, registering, or using ZYMSCAN platform grants you the status of USER.

The USER declares:

• To be of legal age and/or have the legal capacity to contract, in accordance with the general contracting laws of the state where he/she resides.
• That he/she has read, understood, and accepted the full content of these T&C.

ACCEPTANCE:

These T&C constitute a binding agreement between the USER and the OWNER. BY ACCEPTING THE T&C BY TICKING THE CORRESPONDING CHECKBOX, THE USER IS BOUND BY THESE T&C. The continued use of the platform implies acceptance of any changes made to the T&C. In the event that the USER does not accept these T&C, he/she must refrain from using ZYMSCAN, its services, and the Website.

The OWNER expressly requests the USER not to tick the checkbox on "I ACCEPT THE T&C" if he/she has not read this document, does not wish to be bound by the provisions of the general terms and conditions of use contained therein, or if he/she is not authorized to accept them.

This document is an agreement between the USER (or the entity he/she represents) and the OWNER. If you are signing this agreement on behalf of a company you work for, collaborate with, or represent, you declare that you have the legal authority to do so and to bind that company.

THESE TERMS MAY BE MODIFIED AT ANY TIME. THE USER IS OBLIGED TO REVIEW THEM PERIODICALLY, AS THE VERSION APPLICABLE AT THE TIME OF ACCESSING THE PLATFORM WILL BE THE ONE IN FORCE AT THAT TIME. THESE TERMS CAN BE CONSULTED AT ANY TIME AT HTTPS://ZYMBRAIN.AI/TERMS-AND-CONDITIONS/.

DEFINITIONS:

For the purposes of these T&C, the following terms shall be understood to mean:

DESCRIPTION OF THE SERVICE AND PLATFORM OPERATION:

These T&C apply to the ZYMSCAN platform, which is free and involves suggesting enzymes capable of carrying out a specific reaction proposed by the USER.

In addition, general information about the platform, support services for the use of ZYMSCAN and other additional information is made available to the USER, through the Website. For any additional questions, the USER may contact the OWNER by sending an email to zymscan@zymvol.com.

The USER must have the necessary equipment and internet access to use the platform and is responsible for associated expenses. The USER is responsible for obtaining the corresponding access to the platform, including the related costs, such as Internet charges, among others that the access may entail. The USER must have the necessary equipment to access the platform.

The OWNER does not guarantee access from all devices, locations worldwide or wireless service plan. Despite all efforts are made by the OWNER to ensure uninterrupted access, service disruptions, restrictions, or suspensions, they may occur at any time without notice, for which the OWNER will not be held liable.

The USER must create an account to use ZYMSCAN's services and features. To create the said account, the USER must provide:

• First Name.
• Last Name.
• Email.
• Organization Type (Company or Research Center).
• Organization Name.

The USER must also create a password in order to access the account and must accept these T&C and the Privacy Policy in order to create an account.

To use ZYMSCAN the USER is required to register, accept these T&C and receive confirmation email of the activation and validation of his/her account.

For the USER to find the enzyme he/she is looking for through the platform, the following steps must be followed:

• STEP 1: Submit the substrate and product. This can be done in two ways:
  • Standard mode: use natural language or CAS number to find and select the substrate and product.
  • Advanced mode: use SMILES (Simplified Molecular-Input Line-Entry System) of a specific reaction or Draw the molecules.
• STEP 2: Once product and substrate are submitted, click on "ZYMSCAN IT".
• STEP 3: ZYMSCAN will analyze the enzyme landscape and select relevant enzyme families compatible with the target reaction.
• STEP 4/Results: Within 10 seconds, ZYMSCAN will suggest relevant families compatible with the reaction.

Once the USER has registered, he/she will be able to access, view, modify and delete at any time any of the works he/she has developed through the platform. Within the platform, the USER will be able to create and manage projects in which his/her work will be recorded.

The USER undertakes to provide the OWNER with truthful, accurate, and up-to-date personal information and to inform about any changes or modifications that may occur, so that the OWNER can keep the USER's information accurate and precise.

The USER is not authorized and is strictly responsible for creating and account in the name of a third party.

The USER is obliged to keep his/her account secure and is the only person authorized to use it, and it is not authorized to share it or allow third parties access to it.
The USER undertakes to immediately notify the OWNER, by appropriate means, of any unauthorized use of his/her account, suspicion of use by third parties, as well as unauthorised access by third parties. If the USER becomes aware of the use of his/her account by third parties and does not notify the OWNER, the OWNER shall attribute such use by third parties to the USER.

The USER may cancel his/her account at any time by contacting the OWNER via email at zymscan@zymvol.com.

AUTHORIZATION OF USE:

The USER must accept these General Terms and Conditions of Use by ticking the checkbox.

Once the USER accepts these T&C and meets all technical requirements necessary for ZYMSCAN's proper functioning, the OWNER grants the USER a personal, limited, revocable, non-transferable, and non-exclusive authorization to use the platform in one or more designated units, within the agreed-upon territory and duration.

In any case, the rights of the USER in relation to the use of the platform are subject to compliance with these T&C.

The authorization of use does not constitute a sale of the platform or any part of it, nor of any ownership titles or copyrights.

The duration of the authorization begins when the USER starts using the platform and will end upon the occurrence of any of the following:

• The agreed term for the provision of services expires.
• Cancellation or termination by the OWNER of the authorization due to any reasons stated in these T&C.

USER-SUBMITTED CONTENT:

For the use of ZYMSCAN, the USER may upload information and content on the platform. In this case, the USER undertakes to have all necessary rights and authorizations to be entitled to do so and always in accordance with the applicable law.

Likewise, the USER authorizes the OWNER to use the information and content he/she has uploaded in order to train, develop and improve ZYMSCAN as well as for algorithm improvement.

ZYMSCAN's usage also includes purposes like registration and statistical analysis. The OWNER reserves the right to share search results for statistical purposes while ensuring confidentiality.

OBLIGATIONS OF THE OWNER:

The OWNER undertakes to comply with the following essential obligations:

• To ensure the correct use of the platform contracted by the USER, in accordance with these T&C.
• To inform the USER of the hardware and equipment configuration necessary for optimal use of the platform, together with the corresponding instructions.
• To keep the platform updated and notify the USER of any changes made.
• To keep and safeguarde with due diligence the information contained in the USER's account during the authorization of use.

OBLIGATIONS AND PROHIBITIONS OF THE USER:

The USER accepts the following obligations and prohibitions:

• To use the platform in strict compliance with the law and public order, refraining from engaging in illegal or illicit activities or actions contrary to what is established in the T&C.
• Do not damage, disable, overload, or impair the platform nor prevent its normal use or enjoyment.
• Do not attempt to breach access levels, improperly manipulate data, duplicate or export data or information protected by intellectual property or other rights, attempt to access restricted areas of the OWNER's or third-party computer systems, introduce programs, viruses, or any other device that may cause or could potentially cause modifications to the OWNER's or third-party computer systems.
• Do not reproduce the platform, in whole or in part. Reproduction or copying of any part of the documentation in electronic or printed form is permitted for the USER's internal use only when required to exercise the rights granted under this authorization. The USER must include and shall not under any circumstances remove mentions of copyright, trademarks, or any other references to industrial and intellectual property rights that demonstrate the exclusive ownership of the OWNER and its licensors, whether in full or partial copies of the platform, documentation, or proprietary information, in the same form and location as they appear in the original work.
• The USER shall not to modify or alter the platform in any way or by any means and, consequently, cannot develop derivative works or modifications.
• The USER may not to transfer or assign to third parties any of the rights included in this authorization, nor allow third parties to use it. The use of the platform is strictly limited to fulfilling the USER's own needs or the defined purpose. The USER may not rent, lend, sell, distribute, transfer, or sublicense the platform or engage in any activities that violate the obligation to protect the OWNER's or third-party assets. Furthermore, the USER may not use the platform in a manner that is contrary to the legitimate rights and interests of the OWNER or any third party.
• To provide the necessary measures to avoid, including but not limited to: disclosure, copying, duplication, manipulation, reproduction, translation, transformation, or access by third parties, or any other act that violates the obligation to protect third-party assets. The USER must safeguard and physically and logically protect the platform, its contents, logical procedures, and access mechanisms.
• To maintain and use the platform properly and prudently, following the advice and instructions provided by the OWNER periodically, and only allow access to authorized and competent personnel.
• To defend, indemnify, and hold harmless the OWNER and/or its suppliers against any claim or action of any kind, as well as any expense and/or cost (including, but not limited to, legal service fees), arising from or related to the USER's violation of these T&C. This obligation will remain in effect even after the termination of the USER's relationship with the OWNER or the discontinuation of platform use.
• To notify the OWNER of any defect or alleged defect within five (5) days from the date the defect becomes apparent.
• To ensure that he/she has ownership and/or the right to use any information he/she uploads to the platform.
• Do not remove, damage, or disable the security measures implemented by the OWNER on the platform, nor modify its functionalities.
• Do not engage in reverse engineering, decompile, or disassemble the platform.
• Not to create an account on behalf of a third party or impersonate another person.
• Do not conduct vulnerability tests, security flaw searches, load testing, or similar activities without prior authorization from the OWNER.
• Collaborate with the OWNER and comply with his/her recommendations regarding platform use.

WARRANTIES:

To the extent permitted by applicable law, ZYMSCAN is provided "as is," with its defects and without performance guarantees or any other type of warranty. Its use is at the USER's sole risk, who assumes full responsibility for satisfactory quality and performance. The OWNER does not guarantee the viability of the results and warns the USER that they are for guidance only.

The OWNER is not bound by commitments or promises made by individuals outside of his/her organization or by erroneous expectations regarding the platform's functionality. In any case, the USER acknowledges that ZYMSCAN is intended to complement, but not replace, human work.

If the USER detects any errors, he/she must communicate them to the OWNER. Under no circumstances will the OWNER be liable to the USER or third parties for the loss of profits or any damages caused by the failure or malfunction of the platform.

The OWNER does not offer, and hereby disclaims, any implied or express warranties. The OWNER does not guarantee that the USER's enjoyment of the platform will be uninterrupted or without errors, that the application will meet the USER's expectations, that the platform will interoperate or be compatible with third-party applications, or that any errors in the platform will be corrected.

No oral or written advice provided by the OWNER or an authorized representative shall constitute a warranty.

The USER guarantees that he/she has ownership and/or the right to use the information upload to the platform. Consequently, the OWNER will not be held responsible in any way for the origin of this information.

LIABILITIES:

The OWNER will not be held liable for interruptions in ZYMSCAN caused by force majeure or circumstances beyond his/her control.

The OWNER may temporarily suspend access for security reasons or to restructure IT resources, aiming to improve the ZYMSCAN service. These interruptions must be properly justified and will last for the shortest time possible.

The USER acknowledges to be familiar with the hardware, equipment, and technical requirements necessary for the proper use of ZYMSCAN. As a result, the OWNER will not assume any responsibility for inadequacies or violations committed by the USER in the use of ZYMSCAN.

To the maximum extent permitted by applicable law, the OWNER will not be liable to any USER for personal injury, property damage, loss of profits, costs for substitute services or goods, loss of data, financial losses, work stoppages, computer failures or errors, or any direct or indirect damages resulting from the use or contracting of ZYMSCAN, even in cases of breach of contract, strict liability, or otherwise, even if the OWNER had been warned of the possibility of such damages.

The OWNER will not be liable to the USER or any third party for the aforementioned reasons or for any liabilities arising from the USER's use of ZYMSCAN, including but not limited to loss of information or data when using the platform, delays or failures in its use, cases beyond the OWNER's reasonable control, data delivery errors, information processing errors, or legal violations committed by the USER when using ZYMSCAN.

The platform may encounter random circumstances related to hardware, other programs installed on the same device, calculation errors, or errors that are undetectable under normal simulation conditions, as well as errors stemming from the diverse scenarios that may occur. Consequently, the OWNER will not be responsible for operational errors or damages caused by the USER's failure to fulfill obligations, including but not limited to:

• Creating data backups.
• Correctly installing necessary additional tools.
• Maintaining the designated unit that processes the platform.
• Ensuring the computer system and power supply are in good working order.
• Controlling platform access to prevent unauthorized or inexperienced users from making changes.
• Contracting regular maintenance services for hardware and software.
• Implementing preventative measures, including virus and malware protection.

The USER will be solely responsible for providing and covering the costs necessary to ensure ZYMSCAN's compatibility with other accessory applications or computer systems, including hardware, software, electrical components, and other physical components needed to access and use ZYMSCAN, such as telecommunications services, internet access, links, browsers, or other programs and devices.

The use of ZYMSCAN by the USER does not imply that the OWNER approves or acknowledges of how it is used, as the OWNER only provides the platform for proper use in compliance with these T&C and applicable laws. Therefore, the USER is solely responsible for the correct use of ZYMSCAN, as well as for the information and data processing carried out on the platform.

The OWNER will cooperate with judicial or regulatory authorities to identify individuals responsible for any illegal usage. Furthermore, the OWNER disclaims all liability for interruptions in ZYMSCAN or any additional services caused by updates, improvements, or external circumstances.

The USER agrees to hold the OWNER, its directors, administrators, representatives, and employees harmless against any claims or demands from third parties related to activities within ZYMSCAN, additional services, or breaches of these T&C or other legal requirements, or violations of third-party rights or laws.

The USER is not entitled to any compensation, whether direct or indirect, for temporary interruptions or permanent suspension of ZYMSCAN or its additional services, nor for any content, products, or services offered through the platform. The OWNER disclaims any responsibility for such interruptions or suspensions, whether caused by internal or external factors.

If the USER is dissatisfied with any part of ZYMSCAN, its content, or services, or with any part of these T&C, the only and exclusive remedy is to stop using ZYMSCAN and terminate the services provided by the OWNER.

If applicable law does not permit the exclusion of liability for indirect or incidental damages, the OWNER's liability will be limited to the minimum level of guarantees and responsibility permitted by law.

SERVICE SUSPENSION:

The authorization to use and access ZYMSCAN, as well as the provision of any additional services by the OWNER, may be suspended if the USER fails to comply with these T&C and/or if the information provided when creating the account is false or inaccurate.

The OWNER will notify the USER in writing of the reason for the suspension of service. Since thirty (30) days have elapsed since the notification without the USER having resolved, corrected, or remedied the incident that caused the suspension, the OWNER will be entitled to suspend the provision of services for as long as necessary.

The OWNER will reactivate the service once the USER has corrected, rectified, or resolved the issue that led to the suspension.

TERMINATION:

The authorization to use ZYMSCAN will remain in effect until it is terminated.

The rights acquired by the USER under the authorization will be automatically, immediately, and without prior notice revoked by the OWNER if the USER fails to comply with these T&C. Upon termination, the USER must stop using the platform and destroy any copies in his/her possession or under their control.

The authorization to use ZYMSCAN will be terminated if the OWNER, at its sole discretion, determines that the use of the USER of the platform entails a security risk to other users, or if it involves illegal or improper usage, misuse of the provided services, or a violation of the OWNER's industrial and intellectual property rights.

The OWNER may terminate all accounts in response to a violation of these T&C.

The OWNER may issue warnings, suspend accounts, delete or revoke access rights selectively, or confiscate usage rights related to specific accounts or devices. The OWNER may immediately terminate any and all USER accounts or temporarily or permanently ban the USER's designated device or unit from accessing the platform. The USER acknowledges that the OWNER is not obligated to notify he/she of such decision.

If the OWNER terminates the USER's account, the USER may not reaccess the platform without the explicit permission of the service provider.

The USER may not allow his/her account to be used by individuals whose accounts have been terminated by the OWNER.

If the USER believes that any action taken against his/her account was made in error, he/she are advised to contact us at zymscan@zymvol.com.

INTELLECTUAL AND INDUSTRIAL PROPERTY:

The USER acknowledges all industrial and intellectual property rights held by the OWNER over ZYMSCAN, its design, graphics, documentation, and other proprietary information accessible through the platform's use. ZYMSCAN, its additional services, contents, and distinguishing features are protected under national, EU, and international laws governing industrial and intellectual property, as well as the applicable national laws in the country of use.

The industrial and intellectual property rights over ZYMSCAN, the additional services provided by the OWNER, the contents, distinguishing features, and designs included within them—as well as trademarks, trade names, and industrial designs—are the exclusive property of the OWNER, reserved for his/her use and protected by law.

The reproduction, distribution, public communication, transformation, or public availability of all or part of ZYMSCAN or any additional services provided by the OWNER, contents, distinguishing features, designs, trademarks, trade names, and industrial designs included therein is prohibited without prior express authorization from the rightful OWNER.

Consequently, the USER undertakes not to remove, hide, or alter any copyright, patent, trademark, or other intellectual property notices of the OWNER, nor copy or download any content from the program unless expressly authorized.

Unless expressly authorized by the OWNER, the USER may not distribute, publicly perform, display, lease, sell, transmit, transfer, publish, edit, copy, create derivative works, rent, sublicense, distribute, decompile, disassemble, reverse engineer, or make any unauthorized use of the contents or rights held by the OWNER or those present in ZYMSCAN.

By using ZYMSCAN, the USER does not acquire any ownership rights and may only use them as accepted under the T&C.

Unauthorized use or infringement of industrial and intellectual property rights related to ZYMSCAN, its additional services, contents, distinguishing features, designs, trademarks, trade names, and industrial designs will result in corresponding legal liabilities. The USER agrees to indemnify and hold the OWNER harmless from any unauthorized or illegal actions conducted by the ADMINISTRATOR or any user of the equipment.

If the USER detects any activity that may violate any industrial or intellectual property rights or other rights, he/she is requested to report it to zymscan@zymvol.com.

SEARCH RESULTS PROTECTION:

The results of searches conducted by the USER are the property of the USER.

The USER may use the search results he/she generates for academic and commercial purposes. However, under no circumstances may the USER use the results to compete with or harm the interests of ZYMVOL BIOMODELING, S.L.

HARDWARE AND SOFTWARE REQUIREMENTS:

The USER must have the appropriate computer equipment for data communication and management.
The OWNER will not be responsible for issues arising from defects, obsolescence, or general inadequacy of the USER's hardware.

The USER is also responsible for installing the necessary software for the platform's operation and maintaining an updated internet connection.

To ensure the proper functioning of the system, the following components must be installed at a minimum:

• An internet browser.
• Email access.
• IT security systems, such as firewalls and antivirus software.

TECHNICAL SUPPORT:

For technical issues or data-related concerns, the USER may contact the OWNER at zymscan@zymvol.com.

PLATFORM MODIFICATION AND UPDATES:

The OWNER reserves the right to unilaterally modify the presentation, configuration, and content of ZYMSCAN at any time and without prior notice, as deemed appropriate. Access to or partial or total use of ZYMSCAN implies acceptance of the modifications made.

The USER acknowledges and accepts that any obligation ZYMSCAN may have to provide support for previous versions may end once an update, improvement, or implementation of additional functions becomes available.

NULLITY AND INEFFECTIVENESS OF CLAUSES:

If any clause included in these T&C is declared, in whole or in part, null or ineffective, such nullity or ineffectiveness will only affect that specific provision or part thereof, which will be modified to achieve the original intent of the provision to the greatest extent possible, while the rest of these T&C will remain fully in effect.

GENERAL PROVISIONS:

Force Majeure: Neither party shall be held responsible for failure or delay in fulfilling their obligations if such failure or delay is due to riot, war, civil unrest, weather conditions, labor disputes, subcontractor failures, or any other cause beyond the reasonable control of the affected party.

Transfer of Obligations: The USER may not transfer the benefits and obligations acquired under this authorization of use and established in these T&C to third parties without prior written consent and authorization of the OWNER.

Notices: Any notice by one party to the other will be made via email to the address where the receiving party regularly receives information.

PRIVACY POLICY AND COOKIES:

Personal data provided by the USER will be processed in accordance with our Privacy Policy and Cookie Policy.

APPLICABLE LAW AND JURISDICTION:

The use of ZYMSCAN and the Website will be governed by Spanish law.

For any issue or dispute arising from these T&C, the authorization to use ZYMSCAN, the program contents, activities, products, or services contracted, both the OWNER and the USER expressly waive any other jurisdiction that may apply to them and submit to the application of Spanish law. The Spanish courts will have jurisdiction, with explicit submission to the courts of Barcelona, unless the applicable law mandatorily establishes another jurisdiction or different legislation.

COMMENTS, SUGGESTIONS, COMPLAINTS, AND CLAIMS:

If the USER has any comments, suggestions, complaints, or claims regarding these T&C, they should be addressed to the following email: zymscan@zymvol.com.